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dc.contributor.authorFonthal Rico, Farukspa
dc.contributor.authorGarcía Cruz, Jenniferspa
dc.contributor.authorRíos Afanador, Ismael Albertospa
dc.date.accessioned2021-11-11T17:31:25Z
dc.date.available2021-11-11T17:31:25Z
dc.date.issued2019
dc.identifier.issn14243210
dc.identifier.urihttps://hdl.handle.net/10614/13434
dc.description.abstractIn this paper, we introduce a novel type of transdermal drug delivery device (TD3 ) with a micro-electro-mechanical system (MEMS) design using computer-aided design (CAD) techniques as well as computational fluid dynamics (CFD) simulations regarding the fluid interaction inside the device during the actuation process. For the actuation principles of the chamber and microvalve, both thermopneumatic and piezoelectric principles are employed respectively, originating that the design perfectly integrates those principles through two different components, such as a micropump with integrated microvalves and a microneedle array. The TD3 has shown to be capable of delivering a volumetric flow of 2.92 × 10−5 cm3 /s with a 6.6 Hz membrane stroke frequency. The device only needs 116 Pa to complete the suction process and 2560 Pa to complete the discharge process. A 38-microneedle array with 450 µm in length fulfills the function of permeating skin, allowing that the fluid reaches the desired destination and avoiding any possible pain during the insertioneng
dc.format.extent11 páginasspa
dc.format.mimetypeapplication/pdfeng
dc.language.isoengeng
dc.publisherMDPIspa
dc.rightsDerechos reservados - MDPI, 2019spa
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/4.0/eng
dc.titleDesign and analyses of a transdermal drug delivery device (TD3 )eng
dc.typeArtículo de revistaspa
dcterms.audienceGeneralspa
dc.subject.armarcSistemas microelectromecánicosspa
dc.subject.armarcDispositivos electromecánicosspa
dc.subject.armarcSistemas microelectromecánicosspa
dc.subject.armarcMicroelectromechanical systemseng
dc.subject.armarcElectromechanical deviceseng
dc.contributor.corporatenameSensorsspa
dc.publisher.placeBasel, Switzerlandeng
dc.relation.citationeditionVolumen 19, número 23 (2019)spa
dc.relation.citationendpage11spa
dc.relation.citationissueNúmero 23spa
dc.relation.citationstartpage1spa
dc.relation.citationvolumeVolumen 19spa
dc.relation.citesGarcía, J., Ríos, I., Fonthal Rico F. (2019). Design and analyses of a transdermal drug delivery device (TD3). Sensors. (Vol. 19 (23), pp. 1-11. https://doi.org/10.3390/s19235090eng
dc.relation.ispartofjournalSensorseng
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dc.rights.accessrightsinfo:eu-repo/semantics/openAccesseng
dc.rights.creativecommonsAtribución-NoComercial-SinDerivadas 4.0 Internacional (CC BY-NC-ND 4.0)spa
dc.subject.proposalTransdermal drug deliveryeng
dc.subject.proposalMicro-electro-mechanical systems (MEMS)eng
dc.subject.proposalFinite element analysieng
dc.subject.proposalMicrostructureseng
dc.subject.proposalComputational fluid dynamiceng
dc.type.coarhttp://purl.org/coar/resource_type/c_6501eng
dc.type.contentTexteng
dc.type.driverinfo:eu-repo/semantics/articleeng
dc.type.redcolhttp://purl.org/redcol/resource_type/ARTeng
oaire.accessrightshttp://purl.org/coar/access_right/c_abf2eng
oaire.versionhttp://purl.org/coar/version/c_970fb48d4fbd8a85eng
dc.type.versioninfo:eu-repo/semantics/publishedVersioneng


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