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dc.contributor.authorArce Guerrero, Sandraspa
dc.contributor.authorFernández, Tuliospa
dc.contributor.authorOlave, Gilbertospa
dc.contributor.authorValencia, Carlosspa
dc.contributor.authorQuinn, Julianspa
dc.coverage.spatialUniversidad Autónoma de Occidente. Calle 25 115-85. Km 2 vía Cali-Jamundíspa
dc.date.accessioned2020-03-25T19:59:35Zspa
dc.date.available2020-03-25T19:59:35Zspa
dc.date.issued2014-03spa
dc.identifier.citationArce Guerrero, Sandra; Fernández, Tulio; Olave, Gilberto; Valencia, Carlos; Quinn, Julian. Effects of calcium phosphate/chitosan composite on bone healing in rats: calcium phosphate induces osteon formation. En: Tissue Engineering Part A. Volumen 20, número 13-14, (marzo 2014); páginas 1948-1960eng
dc.identifier.urihttp://red.uao.edu.co//handle/10614/12172spa
dc.identifier.urihttps://www.ncbi.nlm.nih.gov/pubmed/24460696eng
dc.descriptionxxxxxeng
dc.description.abstractVascularization of an artificial graft represents one of the most significant challenges facing the field of bone tissue engineering. Over the past decade, strategies to vascularize artificial scaffolds have been intensively evaluated using osteoinductive calcium phosphate (CaP) biomaterials in animal models. In this work, we observed that CaP-based biomaterials implanted into rat calvarial defects showed remarkably accelerated formation and mineralization of new woven bone in defects in the initial stages, at a rate of ∼60 μm/day (0.8 mg/day), which was considerably higher than normal bone growth rates (several μm/day, 0.1 mg/day) in implant-free controls of the same age. Surprisingly, we also observed histological evidence of primary osteon formation, indicated by blood vessels in early-region fibrous tissue, which was encapsulated by lamellar osteocyte structures. These were later fully replaced by compact bone, indicating complete regeneration of calvarial bone. Thus, the CaP biomaterial used here is not only osteoinductive, but vasculogenic, and it may have contributed to the bone regeneration, despite an absence of osteons in normal rat calvaria. Further investigation will involve how this strategy can regulate formation of vascularized cortical bone such as by control of degradation rate, and use of models of long, dense bones, to more closely approximate repair of human cortical boneeng
dc.formatapplication/pdfspa
dc.format.extentpáginas 1948-1960spa
dc.language.isoengeng
dc.publisherTissue Eng Part A.eng
dc.relationTissue Engineering Part A. Volumen 20, número 13-14, (marzo 2014); páginas 1948-1960eng
dc.rightsDerechos Reservados - Universidad Autónoma de Occidentespa
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/4.0/spa
dc.sourceinstname:Universidad Autónoma de Occidentespa
dc.sourcereponame:Repositorio Institucional UAOspa
dc.subjectxxxxxeng
dc.subjectxxxxxeng
dc.titleEffects of calcium phosphate/chitosan composite on bone healing in rats: calcium phosphate induces osteon formationeng
dc.typeArtículo de revistaspa
dc.creator.emailxxxxxspa
dc.identifier.doihttps://doi.org/10.1089/ten.tea.2013.0696eng
dc.rights.accessrightsinfo:eu-repo/semantics/openAccessspa
dc.rights.creativecommonsAtribución-NoComercial-SinDerivadas 4.0 Internacional (CC BY-NC-ND 4.0)spa
dc.type.coarhttp://purl.org/coar/resource_type/c_6501spa
dc.type.contentTextspa
dc.type.driverinfo:eu-repo/semantics/articlespa
dc.type.redcolhttp://purl.org/redcol/resource_type/ARTREFspa
oaire.accessrightshttp://purl.org/coar/access_right/c_abf2spa
oaire.versionhttp://purl.org/coar/version/c_970fb48d4fbd8a85spa
dc.type.versioninfo:eu-repo/semantics/publishedVersionspa
dc.source.bibliographiccitationxxxxxspa


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Derechos Reservados - Universidad Autónoma de Occidente
Except where otherwise noted, this item's license is described as Derechos Reservados - Universidad Autónoma de Occidente